We cannot possibly predict what will happen in the future of the story. Only the author, Tite Kubo, knows such things. He has, however, stated that romance will not play a significant role in the story. While that does not mean that there will be no romance aspect, it will be a relatively minor thing if it occurs. Many people like to cite the Bleach relationship chart that came out a few years ago. The chart was not written by Kubo, it was written by the organizers of the Bleach festival which celebrated Bleach's ten year anniversary. It is nothing but fan fiction.
Ichigo, Rukia, Hitsugaya and Hinamori have not revealed any romantic feelings for any character.
The only canon, confirmed romantic interests in Bleach are:
- Byakuya Kuchiki and Hisana Kuchiki were married;
- Kaien Shiba and Miyako Shiba were married;
- Isshin Kurosaki and Masaki Kurosaki were married;
- Ryūken Ishida and Kanae Katagiri were married.
- Orihime is in love with Ichigo, but it is not known if he returns those feelings;
- Riruka is attracted to Ichigo physically.
- Moe is attracted to Orihime.
- Tatsufusa Enjōji secretly has feelings for Suì-Fēng, but not vice-versa.